C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/46 (2006.01) A61K 31/445 (2006.01) A61K 31/475 (2006.01) A61K 38/08 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2309321
The present invention relates to the field of cancer chemotherapy. More particularly, the present invention relates to a compound for improving the effectiveness of cancer chemotherapy by preventing, reducing, or reversing the development of cellular resistance to chemotherapeutic agents, i.e., the phenomenon known as "multidrug resistance" (MDR), during the course of therapy. This is achieved by administering to patients N-alkyl-1,5-dideoxy-1,5- imino-D-glucitol or galactitol compounds ("iminosugars") in conjunction with chemotherapeutic drugs.
La présente invention porte sur la chimiothérapie anticancéreuse. Plus particulièrement, l'invention porte sur un composé pouvant améliorer l'efficacité de la chimiothérapie anticancéreuse par prévention, réduction ou inversion du développement de la résistance cellulaire aux agents chimiothérapeutiques (phénomène connu sous le nom de "résistance multiple aux anticancéreux" (MDR)) pendant la thérapie. On obtient ce résultat en administrant à des patients des composés de N-alkyl-1,5-didéoxy-1,5-imino-D-glucitol ou galactitol ("iminosucres") conjointement avec des médicaments chimiothérapeutiques.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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