A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/55 (2006.01) A61P 17/02 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2446197
The invention relates to the use of alpha 1-antichymotrypsin (ACT) polypeptides according to SEQ ID No. 1 to SEQ ID No. 4 and/or nucleic acids encoding them, or an antibody or a fragment thereof directed against the polypeptide, or of a cell which is expressing the polypeptide or a nucleic acid encoding it, for diagnosis, treatment and/or prevention of diabetes- associated and/or arterial wounds which heal poorly and for identifying pharmacologically active substances which exert an influence on the expression or function, particularly the activity of ACT.
La présente invention concerne l'utilisation de polypeptides alpha 1-antichymotrypsine (ACT) correspondant aux séquences comprises entre la SEQ ID No. 1 et la SEQ ID No. 4 et/ou d'acides nucléiques codant ces derniers, ou bien d'un anticorps ou d'un fragment de ce dernier, dirigé contre le polypeptide, ou encore d'une cellule qui exprime le polypeptide ou un acide nucléique codant ce dernier, pour le diagnostic, le traitement et/ou la prophylaxie des plaies artérielles et/ou associées au diabète qui se cicatrisent difficilement et pour identifier des substances actives du point de vue pharmacologique qui exercent une influence sur l'expression ou la fonction, notamment sur l'activité de l'ACT.
Goppelt Andreas
Halle Jorn-Peter
Hof Peter
Bayer Innovation Gmbh
Goudreau Gage Dubuc
Switch Biotech Ag
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