Use of alpha-hydroxy carbonyl compounds as reducing agents

Details Use of alpha-hydroxy carbonyl compounds as reducing agents Use of alpha-hydroxy carbonyl compounds as reducing agents

A - Human Necessities

61

K

A61K 31/045 (2006.01) A61K 31/12 (2006.01)

Patent

CA 2635388

There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction- activated prodrugs . Examples of the alpha-hydroxycarbonyl compounds used are dihydroxyacetone, glycolaldehyde , glyceraldehyde, erythrose, xylulose, erythrulose or 3-hydroxy-2-butanone.

La présente invention concerne l~utilisation de composés .alpha.-hydroxycarbonyle en tant qu'agents réducteurs capables de former des dimères cycliques. La présente invention concerne également les procédés correspondants destinés à réduire des composés réductibles, en particulier des pro-médicaments activés par réduction.

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