Use of .alpha.-msh and epo for preventing or treating...

Details Use of .alpha.-msh and epo for preventing or treating... Use of .alpha.-msh and epo for preventing or treating...

A - Human Necessities

61

K

A61K 38/34 (2006.01) A61K 38/13 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2407785

The present invention relates to a method for treating or preventing ischemia induced organ dysfunction. The method comprises administration of an effective dose of .alpha.-MSH and/or an .alpha.-MSH equivalent and EPO and/or an EPO equivalent to an individual in need thereof. Examples of ischemic conditions, which may be treated according to the present invention, are: Ischemia induced renal failure, myocardial ischemia, intestinal ischemia and cerebral ischemia. In various animal models of ischemia the combination of .alpha.-MSH and rh-EPO has been shown to have a synergistic effect in reversing the adverse effects of the ischemia.

La présente invention a pour objet un procédé pour traiter ou prévenir les dysfonctionnements d'organes induits par une ischémie. Ce procédé consiste à administrer une dose efficace de .alpha.-MSH et/ou un équivalent de .alpha.-MSH et de l'EPO et/ou un équivalent d'EPO à un sujet. Ce procédé permet de traiter des conditions ischémiques telles que l'insuffisance rénale induite par ischémie, l'ischémie myocardique, l'ischémie intestinale et l'ischémie cérébrale. Dans divers modèles d'ischémie chez l'animal, l'association de .alpha.-MSH et de rh-EPO a démontré un effet de synergie pour inverser les effets défavorables de l'ischémie.

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