Use of alpha receptor antagonists for the treatment of...

Details Use of alpha receptor antagonists for the treatment of... Use of alpha receptor antagonists for the treatment of...

A - Human Necessities

61

K

A61K 31/417 (2006.01) A61K 31/138 (2006.01) A61K 31/395 (2006.01) A61K 45/06 (2006.01) A61P 21/00 (2006.01)

Patent

CA 2174133

Methods are provided for intramuscular needle diagnosis and treatment of muscle pain that is the result of sympathetically mediated spindle spasm. Two simultaneous needle EMG needle recordings are used to establish the presence of and magnitude of the "trigger points" in painful muscle. The abnormal muscle activity so identified is then treated by blocking the sympathetic activation of the muscle with an alpha receptor antagonist, e.g. phentolamine, phenoxybenzamine and guanethidine.

L'invention concerne des procédés de diagnostic et de traitement au moyen d'une aiguille intramusculaire de la douleur musculaire résultant des spasmes du fuseau neuromusculaire induits de manière sympathique. Deux tracés d'électromyographie par aiguille simultanés sont utilisés pour établir la présence de points de déclenchement et leur ampleur dans un muscle douloureux. L'activité musculaire ainsi identifiée est traitée par blocage de l'activation sympathique du muscle moyen d'un antagoniste du récepteur alpha tel que la phentolamine, la phénoxybenzamine et la guanéthidine.

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