A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/40 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2655133
Vaccines comprising an S. aureus alpha-toxin antigen and a pharmaceutically acceptable carrier are provided, and are useful for treating and preventing infections. The S. aureus alpha-toxin antigen may contain at least two alterations that reduce its toxicity and/or may be conjugated to or co-administered with another bacterial antigen. The vaccines may comprise one or more other bacterial antigens. Antibody compositions comprising antibodies to alpha-toxin and optionally one or more other bacterial antigens also are provided, and are useful for treating and preventing infections.
La présente invention concerne des vaccins contenant un antigène de toxine alpha de S. aureus et un support pharmaceutiquement acceptable, qui se révèlent utiles pour le traitement et la prévention d'infections. L'antigène de toxine alpha de S. aureus peut contenir au moins deux modifications qui réduisent sa toxicité et/ou il peut être conjugué ou co-administré avec un autre antigène bactérien. Les vaccins peuvent contenir un ou plusieurs autres antigènes bactériens. L'invention concerne également des compositions d'anticorps qui contiennent des anticorps dirigés contre la toxine alpha et, éventuellement, un ou plusieurs autres antigènes bactériens, et se révèlent utiles pour le traitement et la prévention d'infections.
Fattom Ali I.
Taylor Kimberly L.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Glaxosmithkline Biologicals Sa
Nabi Biopharmaceuticals
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