Use of amino-oxy functional groups in the preparation of...

A - Human Necessities – 61 – K

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A61K 39/39 (2006.01) A61K 39/385 (2006.01) A61P 37/04 (2006.01) C07K 1/107 (2006.01)

Patent

CA 2758323

The invention relates to a process for preparing a conjugate comprising combining an amino-oxy homofunctional or heterofunctional reagent with an entity chosen from polysaccharides, oligosaccharides, carbohydrates, and carbohydrate-containing molecules containing at least one carbonyl group, to form a polysaccharide, oligosaccharide, carbohydrate, or carbohydrate- containing molecule functionalized via at least one oxime linkage. The functionalized compound is then reacted either directly or indirectly with a protein molety to form a protein-carbohydrate conjugate that may be used as a vaccine.

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