Use of aminothiolester derivatives in pharmaceutics

Details Use of aminothiolester derivatives in pharmaceutics Use of aminothiolester derivatives in pharmaceutics

A - Human Necessities

61

K

A61K 31/265 (2006.01)

Patent

CA 2257898

The invention concerns the use of at least an aminothiolester derivative for preparing a pharmaceutical composition for lifting the inhibition of a characteristic resistant to apoptosis induction in transformed cells, said characteristic arising from the presence of bcl2 gene in said cells. The pharmaceutical composition is more particularly for treating pathologies including breast cancer, B cell lymphoma, leukaemia, neuroblastoma, prostate adenocarcinoma, prolactinoma and other pituitary adenomas.

Utilisation, pour la préparation d'une composition pharmaceutique destinée à lever l'inhibition d'un caractère résistant à l'induction d'apoptose de cellules transformées, ce caractère étant dû au gène bc12 présent dans ces cellules, d'au moins un dérivé aminothiolester de formule (I) suivante: (voir formule I) dans laquelle R1, R2 et R3 indépendamment, représentent un radical alkyle, linéaire ou ramifié, saturé ou insaturé de C1 à C6. La composition pharmaceutique est plus particulièrement destinée à traiter les pathologies choisies parmi les cancers du sein, les lymphomes des cellules B, les leucémies, le neuroblastomes, les adénocarcinomes de la prostate, les prolactinomas et autres adénomes pituitaires.

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