Use of amphiregulin as a protective agent in acute hepatic...

Details Use of amphiregulin as a protective agent in acute hepatic... Use of amphiregulin as a protective agent in acute hepatic...

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01)

Patent

CA 2574507

The invention relates to the use of amphiregulin in the production of a medicament which can be used to treat acute hepatic injury and which is administered, for example, in order to: promote a primary endogenous protective reaction in the hepatic tissue against acute hepatic injury, promote DNA synthesis in hepatocytes, prevent the death of hepatocytes in the hepatic tissue of patients with acute hepatic injury, stimulate the regeneration of the remaining hepatic parenchyma following an acute hepatic injury of any aetiology, and stimulate hepatic regeneration following a partial hepatectomy. According to the invention, the amphiregulin is administered as a hepatoprotector medicine for patients with acute hepatic injury of any aetiology and/or as a hepatoprotector medicine and stimulant of hepatocytic regeneration for recipients of a liver transplant from a living donor or a cadaver donor.

Utilisation de l'amphiréguline dans la fabrication d'un médicament utile pour le traitement de lésions hépatiques aiguës que l'on administre, par exemple, pour favoriser une réaction protectrice endogène primaire du tissu hépatique contre la lésion hépatique aiguë, dans le but de favoriser la synthèse de l'ADN en hépatocytes. Ainsi, on prévient la mort d'hépatocytes dans le tissu hépatique chez des patients souffrant d'une lésion hépatique aiguë, on stimule la régénération du parenchyme hépatique restant après une lésion hépatique aiguë d'une quelconque éthiologie, on stimule la régénération hépatique après une hépatectomie partielle, sous forme de médicament hépatoprotecteur administré à des patients souffrant d'une lésion hépatique aiguë d'une quelconque éthiologie et/ou sous forme de médicament hépatoprotecteur et stimulant de la régénération hépatocytaire chez des patients récepteurs d'une transplantation hépatique en provenance de donneurs vivants ou de cadavres.

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