Use of an agent inducing dopachrome tautomerase (trp-2)...

A - Human Necessities – 61 – K

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Details

A61K 8/34 (2006.01) A61Q 5/00 (2006.01) A61Q 7/00 (2006.01)

Patent

CA 2486544

The invention concerns the cosmetic use of an agent inducing DOPAchrome tautomerase expression as protective agent for hair follicle melanocytes. The invention also concerns specific cosmetic compositions for fighting against canities comprising in a cosmetically acceptable medium at least an agent inducing DOPAchrome tautomerase (TRP-2) expression and their uses. The invention further concerns a method for treating canities and a method for preserving natural pigmentation of grey or white hair and/or hairs by applying a cosmetic composition comprising at least an agent inducing DOPAchrome tautomerase expression. Finally, the invention concerns a method for identifying an agent inducing DOPAchrome tautomerase (TRP-2) expression and a method for evaluating its cytoprotective activity.

La présente invention se rapporte à ('utilisation cosmétique d'un agent inducteur de ('expression de la DOPAchrome tautomérase, en tant qu'agent protecteur des mélanocytes du follicule pileux. L'invention concerne également des compositions cosmétiques particuliers pour lutter contre la canitie comprenant dans un milieu cosmetiquement acceptable au moins un agent inducteur de ('expression de DOPAchrome tautomérase (TRP-2) et à leurs utilisations. L'invention se rapporte également a un procédé de traitement de la canitie ainsi qu'a un procédé de maintien de la pigmentation naturelle des cheveux et/ou des poils gris ou blancs par l'application d'une composition cosmétique comprenant au moins un agent inducteur de l'expression de la DOPAchrome tautomérase. L'invention se rapporte en outre a une méthode pour identifier un agent inducteur de l'expression de la DOPAchrome tautomérase (TRP-2) ainsi qu'a une méthode d'évaluation de son activité cytoprotectrice.

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