A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/415 (2006.01) A61K 31/4174 (2006.01) A61K 31/4178 (2006.01)
Patent
CA 2303217
The present invention relates to the use, for the preparation of drugs to increase the survival rate of transplant patients, including renal and heart transplant patients, of a therapeutically effective amount of an angiotensin II receptor antagonist compound, such as the class of substituted imidazoles represented by formula (I) and in particular by losartan potassium, 2-butyl-4-chloro-1-[(2'-tetrazol-5-yl)biphenyl-4-il]methyl]-5- (hydroxymethyl)imidazole potassium salt.
Dans le but de préparer des médicaments servant à augmenter le taux de survie de patients transplantés, notamment les patients ayant subi une transplantation rénale et les patients ayant subi une transplantation cardiaque, cette invention propose d'utiliser, en quantité efficace sur le plan thérapeutique, un composé antagoniste du récepteur de l'angiotensine II, tel que les composés appartenant à la classe des imidazoles substituées représentées par la formule (I), et en particulier le potassium de losartan, sel potassium de 2-butyl-4-chloro-1-[(2'-tétrazol-5-yl)biphényle-4-il]méthyle]-5-(hydroxyméthyl)imidazole.
Fetherstonhaugh & Co.
Merck Sharp & Dohme (italia) S.p.a.
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