Use of an antagonist of il-6 for treating il-6-mediated...

Details Use of an antagonist of il-6 for treating il-6-mediated... Use of an antagonist of il-6 for treating il-6-mediated...

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2539061

Use of a compound comprising at least a structural entity which binds or is an antagonist for interleukin-6 (IL-6) and/or the IL-6 receptor or parts of it, preferably human IL-6 which compound depletes IL-6 from a solution or blocks at least one or more IL-6 functions on cell surfaces or in a solution for manufacturing of a medicament for the treatment or prevention of diseases selected from the group consisting of endothelial injury, destruction, increased risk for endothelial injury or destruction or immune disorders other than rheumatoid arthritis and combinations thereof.

Cette invention se rapporte à l'utilisation d'un composé comprenant au moins une entité structurelle qui est un liant ou un antagoniste pour l'interleukine-6 (IL-6) et/ou le récepteur de l'IL-6 ou de parties de celle-ci, de préférence l'IL-6 humaine. Ce composé retire l'IL-6 d'une solution ou bloque au moins une ou plusieurs fonctions d'IL-6 sur des surfaces de cellules ou dans une solution servant à la fabrication d'un médicament pour le traitement ou la prévention des maladies choisies dans le groupe composé des lésions endothéliales, des destructions, des risques accrus de lésions endothéliales ou de destructions ou d'affections immunes autres que la polyarthrite rhumatoïde et des combinaisons de celles-ci.

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