Use of an antagonist of ppar-alpha and ppar-gamma for the...

A - Human Necessities – 61 – K

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A61K 31/44 (2006.01) A61K 31/00 (2006.01) A61K 31/42 (2006.01) A61K 31/423 (2006.01) A61K 31/4402 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2242632

A method for the treatment and/or prophylaxis of Syndrome X in a human or non- human mammal, which method comprises the administration of an effective, non- toxic and pharmaceutically effective amount of an agonist of PPAR.alpha. and PPAR.gamma., or a pharmaceutically acceptable derivative thereof, to a human or non-human mammal in need of such treatment, and certain compound for use in such method.

Selon le procédé décrit de traitement et/ou de prophylaxie du syndrome X chez un être humain ou mammifère non humain, on administre une dose efficace, non toxique et pharmaceutiquement efficace d'un agoniste du récepteur-.alpha. activé de la prolifération des peroxysomes (PPAR.alpha.) et du récepteur-.gamma. activé de la prolifération des peroxysomes (PPAR.gamma.), ou d'un dérivé pharmaceutiquement acceptable de ceux-ci, à un être humain ou à un mammifère non humain ayant besoin d'un tel traitement. L'invention concerne également un composé spécifique utilisé pour mettre en oeuvre ce procédé.

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