A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 48/00 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) C07K 14/26 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2362192
The invention concerns the use of an enterobacterium OmpA membrane protein, in particular of Klebsiella pneumoniae associated with an antigen or a hapten for preparing a pharmaceutical composition for generating or enhancing a cytotoxic T response directed against an infectious or tumor cell. The invention also concerns the use of said compounds for preventing and treating infection or cancer, in particular cancers associated with a tumoral antigen such as melanoma, and pharmaceutical compositions comprising some of said compounds.
L'invention concerne l'utilisation d'une protéine de membrane OmpA d'entérobactérie, notamment de Klebsiella pneumoniae, associée à un antigène ou un haptène pour la préparation d'une composition pharmaceutique destinée à générer ou accroître une réponse T cytotoxique dirigée contre un agent infectieux ou une cellule tumorale. L'invention comprend l'utilisation de ces composés pour la prévention et le traitement d'infection ou de cancer, notamment les cancers associés à un antigène tumoral tels que le mélanome, ainsi que des compositions pharmaceutiques comprenant certains de ces composés.
Bonnefoy Jean-Yves
Renno Toufic
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Pierre Fabre Medicament
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