Use of an enzymatically converted starch derivative as an...

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B01J 13/00 (2006.01) A23L 1/00 (2006.01) A23L 1/0522 (2006.01) A23L 1/09 (2006.01) A23L 1/22 (2006.01) A23L 1/302 (2006.01) A23L 2/56 (2006.01) A23P 1/04 (2006.01) A61K 8/11 (2006.01) A61K 8/73 (2006.01) A61K 9/20 (2006.01) A61K 47/36 (2006.01) A61Q 15/00 (2006.01) A61Q 19/00 (2006.01) C08B 30/12 (2006.01) C08B 31/04 (2006.01) C11D 3/22 (2006.01) C11D 3/50 (2006.01) C11D 17/00 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2252314

The present invention relates to modified starches which are prepared by enzymatic hydrolysis of a starch molecule after the preparation of a starch derivative containing a hydrophobic group or both a hydrophobic and a hydrophilic group, particularly octenyl succinic anhydride starch hydrolyzed by .beta.-amylase or glucoamylase. Such modified starches are useful as encapsulating agents, particularly in systems where high load and retention of the active ingredient, low surface oil exposure, and excellent oxidation resistance is desired. The encapsulating agents are useful in a variety of applications including a tablet in which the starch allows for good compressibility and hardness.

L'invention concerne des amidons modifiés qui sont préparés par hydrolyse enzymatique d'une molécule d'amidon après la préparation d'un dérivé de l'amidon contenant un groupement hydrophobe ou à la fois un groupement hydrophobe et un groupement hydrophile, en particulier un anhydride octénylsuccinique hydrolysé par la .bêta.-amylase ou la glucoamylase. De tels amidons modifiés sont utiles comme agents d'encapsulage, notamment dans des systèmes où l'on désire une charge et une rétention importantes du principe actif, une faible exposition de la surface à l'huile et une excellente résistance à l'oxydation. Les agents d'encapsulage sont utiles dans une diversité d'applications, y compris un comprimé dans lequel l'amidon permet une bonne compressibilité et dureté.

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