C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2217450
An isolated polypeptide which inhibits the replication of retroviruses in peripheral blood lymphocytes and i) is coded by the DNA sequence shown in SEQ ID NO: 1 or complementary sequences; ii) is coded by DNA sequences which hybridize with SEQ ID NO: 1 or SEQ ID NO: 3 under stringent conditions; iii) is coded by DNA sequences which, if there was no degeneracy of the genetic code would hybridize under stringent conditions with the sequences defined in i) to ii); is useful as a therapeutic agent for the treatment of viral infections and benign and malignant proliferation diseases.
L'invention concerne un polypeptide purifié qui inhibe la réplication de rétrovirus dans les lymphocytes du sang périphérique. Ce polypeptide est i) codé par la séquence d'ADN correspondant à SEQ ID NO 1 ou des séquences complémentaires, ii) par les séquences d'ADN capables de former des hybrides avec SEQ ID NO: 1 ou SEQ ID NO:3 dans des conditions bien précises et iii) par des séquences d'ADN qui, s'il n'y avait aucune dégénérescence du code génétique, pourraient former des hybrides dans des conditions précises avec les séquences définies par i) et ii). Ce polypeptide est utile comme agent thérapeutique pour le traitement d'infections virales et de maladies proliférantes bénignes et malignes.
Baier Michael
Kurth Reinhard
Metzner Karin
Werner Albrecht
Bundesrepublik Deutschland (federal Republic Of Germany) Represented By The Federal Minister For Health
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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