Use of an inhibitor or antagonist against tissue factor

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61K 38/28 (2006.01) A61K 48/00 (2006.01) A61P 3/10 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) C07K 16/28 (2006.01) C07K 16/36 (2006.01)

Patent

CA 2476832

The present invention relates to use of an inhibitor or antagonist against tissue factor, TF, in the production of a drug for treatment or prevention of diabetes or diabetes related diseases. The inhibitor or antagonist is mainly intended for treatment of diabetic patients suffering from type I or type II diabetes, respectively, as well as the metabolic syndrome preceding type II diabetes. The inhibitor or antagonist is an agent which completely or partially inhibits TF productions, such as an anti-TF antibody or an antisense construct acting on the TF gene.

La présente invention concerne l'utilisation d'un inhibiteur ou antagoniste du facteur tissulaire (TF) dans la production d'un médicament destiné au traitement ou à la prévention du diabète ou des maladies liées au diabète. Cet inhibiteur ou cet antagoniste est principalement destiné au traitement de patients diabétiques souffrant du diabète respectivement de type I ou II ainsi que du syndrome métabolique précédant le diabète de type II. Cet inhibiteur ou cet antagoniste est un agent qui inhibe complètement ou partiellement les productions TF, telles qu'un anticorps anti-TF ou une construction antisens agissant sur le gène TF.

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