C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/00 (2006.01) A61K 31/145 (2006.01) A61K 31/17 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/505 (2006.01) A61K 31/513 (2006.01) G01N 33/48 (2006.01) G01N 33/50 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2164641
The present invention provides methods for treating autoimmune diseases in mammals and for preventing or treating transplantation rejection in a transplant recipient. The methods of treatment involve the use of drugs capable of suppressing expression of MHC Class I molecules. In particular the use of the drug methimazole to suppress expression of MHC Class I molecules in the treatment of autoimmune diseases and the prevention or treatment of rejection in a transplant recipient is disclosed. In addition in vivo and in vitro assays are provided for the assessment and development of drugs capable of suppressing MHC Class I molecules.
La présente invention concerne des procédés de traitement des maladies autoimmunes chez les mammifères et des procédés de prévention ou de traitement des rejets de greffe chez un receveur de greffe. Les procédés de traitement consistent à utiliser des médicaments capables de supprimer l'expression des molécules MHC de la classe I. En particulier, l'utilisation du méthimazole en tant que médicament médicament permet de supprimer l'expression des molécules de la classe I du complexe majeur d'histocompatibilité (CMH) dans le traitement des maladies autoimmunes et la prévention ou le traitement du rejet chez un receveur de greffe. De plus, des dosages in vivo sont prévus pour tester et élaborer des médicaments capables de supprimer les molécules de la classe I du complexe majeur d'histocompatibilité (CMH).
Kohn Leonard
Ledley Fred D.
Mozes Edna
Napolitano Giorgio
Saji Motoyasu
Baylor College Of Medicine
Secretary Department Of Health And Human Services (the)
Smart & Biggar
LandOfFree
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