A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/108 (2006.01) A61K 9/00 (2006.01) A61K 39/155 (2006.01) A61K 39/385 (2006.01) A61P 31/14 (2006.01) C07K 14/135 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2385404
The invention concerns the use of an outer membrane protein A (OmpA) of enterobacterium, in particular protein P40 of Klebsiella pneumoniae, associated with an immunogenic peptide derived from the respiratory syncytial virus (RSV) for preparing a pharmaceutical composition for intranasal administration designed to induce an immune response protecting the upper and lower (lungs) respiratory route against RSV infection. The invention also concerns the use of said compounds for preparing a vaccine for preventing and treating RSV infection.
L'invention concerne l'utilisation d'une protéine de membrane OmpA d'entérobactérie, notamment la protéine P40 de Klebsiella pneumoniae, associée à un peptide immunogène dérivé du virus respiratoire syncytial (VRS) pour la préparation d'une composition pharmaceutique administrable par voie nasale destinée à induire une réponse immunitaire protectrice de la voie respiratoire supérieure et de la voie inférieure (poumons) d'un sujet contre l'infection par le VRS. L'invention comprend l'utilisation de ces composés pour la préparation de vaccin destiné à la prévention et le traitement d'infection par le VRS.
Corvaia Nathalie
Goestch Liliane
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Pierre Fabre Medicament
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