A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/403 (2006.01)
Patent
CA 2157488
A new use of, and method of treat- ment using, a compound selected from the group consisting essentially of compounds of formula (I) wherein: R1 is hydrogen, (I) lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naph- Image thoyl; R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl; R3 is hydrogen or lower alkyl of up to 6 car- bon atoms; R4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R4 together with R5 can represent -CH2-O-; X is a valency bond, CH2, oxy- gen or sulfur, Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl; R5 and R6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a CONH2- group, lower alkoxy of up to 6 carbon atoms, ben- zyloxy, lower alkylthio of up to 6 carbon atoms, lower alksulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms; or R5 and R6 together represent methylenedioxy; or a pharmaceutically acceptable salt thereof, for inhibition of proliferation of smooth muscle cells. The new use of, and method of treatment using, the present antiproliferative compounds prevent restenosis following percutaneous transluminal coronary angioplasty (PTCA) and prevent development of atherosclerosis.
Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Bec Partnership No. 1
Gowling Lafleur Henderson Llp
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