Use of and some novel imidazopyridines

Details Use of and some novel imidazopyridines Use of and some novel imidazopyridines

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 11/06 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2495511

The use of compounds of formula (I) wherein R1, R3, R10, m and Ar are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed. Certain novel compounds of formula (I), together with processes for their preparation, compositions containing them and their use in therapy are also disclosed.

Cette invention concerne l'utilisation de composés représentés par la formule (I), dans laquelle R?1¿, R?3¿, R?10¿, m et Ar sont comme définis dans le descriptif, ainsi que des sels de ces composés acceptables au plan pharmaceutique, entrant dans la fabrication d'un médicament destinés au traitement ou à la prophylaxie de maladies ou d'états pour lesquels l'inhibition de l'activité de la kinase Itk est utile. L'invention concerne également certains composés représentés par la formule (I), leurs méthodes de fabrication, des compositions les renfermant, et leur utilisation à des fins thérapeutiques.

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