Use of angiotensin 1-7 for enhancing cardiac function

Details Use of angiotensin 1-7 for enhancing cardiac function Use of angiotensin 1-7 for enhancing cardiac function

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2481221

The invention provides a use of angiotensin-(1-7), or a functional part, derivative and/or analogue thereof, for the preparation of a medicament for enhancing cardiac function. For instance, left ventricular diastolic pressure, coronary flow, endothelial function and/or myocyte hypertrophy can be enhanced by a medicament of the invention. By enhancing cardiac function, the development of heart failure can be attenuated or prevented. The invention further comprises a pharmaceutical composition comprising angiotensin-(1-7), or a functional part, derivative and/or analogue thereof, and a carrier. A method for treating an animal suffering from, or at risk of suffering from, heart failure comprising administering to said animal a pharmaceutical composition of the present invention is also provided herein.

L'invention concerne une utilisation d'angiotensine-(1-7), ou une partie fonctionnelle, un dérivé et/ou un analogue de ce composé, dans la préparation d'un médicament permettant d'améliorer la fonction cardiaque. Ce médicament peut améliorer, par exemple, la pression diastolique ventriculaire gauche, le flux coronaire, la fonction endothéliale et/ou l'hypertrophie du myocyte. L'amélioration de la fonction cardiaque permet d'atténuer ou de prévenir le développement d'une insuffisance cardiaque. L'invention concerne, de plus, une composition pharmaceutique comprenant une angiotensine-(1-7), ou une partie fonctionnelle, un dérivé et/ou un analogue de celle-ci, et un excipient. L'invention concerne en outre un procédé de traitement d'un animal atteint ou ayant le risque d'être atteint d'une insuffisance cardiaque ; ce procédé consistant à administrer audit animal une composition pharmaceutique de l'invention.

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