Use of annellated pyrrole compounds in the treatment of...

Details Use of annellated pyrrole compounds in the treatment of... Use of annellated pyrrole compounds in the treatment of...

A - Human Necessities

61

K

A61K 31/40 (2006.01)

Patent

CA 2457540

Treating or preventing degeneration or destruction of articular cartilage and/or subchondral bone in the affected joint of a mammal is accomplished by administering a compound of formula (I), wherein the variables have the meanings given in the present description. A preferred compound of formula (I) is formula (II). This treatment ameliorates, diminishes, actively treats, reverses or prevents any injury, damage or loss of articular cartilage or subchondral bone subsequent to sa id early stage of said degeneration.

On effectue le traitement ou la prévention de la dégénérescence ou de la destruction d'un cartilage articulaire et/ou d'un os sous-chondral d'une articulation atteinte chez un mammifère en administrant à celui-ci un composé représenté par la formule (I), dans laquelle les variables ont les significations données dans les pièces descriptives de la demande. Un composé préféré de formule (I) est représenté par la formule (.alpha.). Ce traitement atténue, réduit, traite activement, inverse ou prévient les lésions, dommages ou pertes d'un cartilage articulaire ou d'un os sous-chondral une fois passée la phase initiale de cette dégénérescence.

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