Use of antagonists of hepatic sympathetic nerve activity

A - Human Necessities – 61 – K

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A61K 31/46 (2006.01) A61K 31/00 (2006.01) A61K 31/138 (2006.01) A61K 31/44 (2006.01) A61P 3/10 (2006.01) A61P 5/48 (2006.01)

Patent

CA 2538415

The present invention provides pharmaceutical compositions comprising antagonists of hepatic sympathetic activity and methods for using said pharmaceutical compositions for treatment of hyperglycemia, hyperinsulinaemia, hyperlipidaemia, hypertriglyceridaemia, diabetes, insulin resistance, impaired glucose metabolism, conditions of impaired glucose tolerance, conditions of impaired fasting plasma glucose, obesity, diabetic retinopathy, diabetic nephropathy, glomerulosclerosis, diabetic neuropathy, syndrome X, renal failure, sexual dysfunction, chronic stress, and anxiety.

La présente invention concerne des compositions pharmaceutiques comprenant des antagonistes de l'activité sympathique hépatique ainsi que des méthodes d'utilisation de ces compositions pharmaceutiques pour traiter l'hyperglycémie, l'hyperinsulinémie, l'hyperlipidémie, l'hypertriglycéridémie, le diabète, l'insulino-résistance, les troubles du métabolisme glucosique, les affections liées à l'intolérance au glucose, les affections liées aux troubles de la glycémie plasmatique à jeun, l'obésité, la rétinopathie diabétique, la néphropathie diabétique, la glomérulosclérose, la neuropathie diabétique, le syndrome X, l'insuffisance rénale, la dysfonction sexuelle, le stress chronique et l'anxiété.

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