Use of anti-mullerian hormone alone or in combination with...

Details Use of anti-mullerian hormone alone or in combination with... Use of anti-mullerian hormone alone or in combination with...

A - Human Necessities

61

K

A61K 31/565 (2006.01) A01K 67/00 (2006.01) A61K 31/395 (2006.01) A61K 31/44 (2006.01) A61K 38/22 (2006.01) C07K 14/575 (2006.01)

Patent

CA 2067014

JLT24Y 18385Y TITLE OF THE INVENTION USE OF ANTI-MULLERIAN HORMONE ALONE OR IN COMBINATION WITH AROMATASE INHIBITORS FOR REVERSAL OF FEMALE SEXUAL PHENOTYPE IN POULTRY ABSTRACT OF THE INVENTION Fertilized poultry embryos are treated with fowl anti- mullerian hormone which may function as an aromatase inhibitor and may also have a trophic effect on developing gonads. Fertilized poultry embryos are also treated with steroid biosynthesis inhibitors or antagonists which prevents the conversion of androgens to estrogens, and anti-mullerian hormone (AMH). By blocking the production of estrogens and enhancing the gonads the genotypic female is converted into a phenotypic male. The phenotypic conversion of females to males gives the treated birds the advantage of male growth characteristics. A single administration of the combination prior to about day 9 of embryonic incubation results in an irreversible change in sexual phenotype which results in enhanced weight gain and feed efficiency.

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