Use of antibody/antigen interactions entities to protect or...

Details Use of antibody/antigen interactions entities to protect or... Use of antibody/antigen interactions entities to protect or...

A - Human Necessities

61

K

167/139, 167/37

A61K 47/00 (2006.01) A61K 39/395 (2006.01)

Patent

CA 1307737

Abstract of the Disclosure A complex can be produced, comprising (i) an molecule having a biological activity and (ii) an antibody entity recognizing the molecule, that displays biological activity which is inactivation- resistant, relative to that of the molecule. The biologically active molecule can be an enzyme, for example, and can be used to produce a complex with an antibody or antigen-binding protein that resists inactivation resulting from a physical, chemical or biological process. Thus, the inactivation-resistant complex displays prolonged activity under conditions characterized by disrupting temperature, the presence of a proteolytic enzyme, disrupting pH, the presence of an oxidizing agent and/or the presence of an alcohol, among others.

569368

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