Use of antigenic complexes of hiv envelope and hla class i...

Details Use of antigenic complexes of hiv envelope and hla class i... Use of antigenic complexes of hiv envelope and hla class i...

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) A61P 37/02 (2006.01) C07K 14/16 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2344466

Immunogenic compositions able to induce a protection against human immunodeficiency virus type 1 and type 2 (HIV-1 and HIV-2) and their applications. Said compositions comprise a multimolecular complex, a mixture or particles comprising essentially a first compound selected in the group consisting of HIV Env gp120 glycoprotein, gp160 glycoprotein, and specific epitopes thereof, and a second compound selected in the group consisting of HLA class I heavy chain (HC), associated or not with .beta.2 microglobulin, and fragments thereof.

L'invention concerne des compositions immunogènes permettant d'induire une protection contre le virus de l'immunodéficience humaine de type 1 et de type 2 (VIH1-VIH2) et leurs applications. Lesdites compositions comprennent un complexe multimoléculaire, un mélange ou des particules comprenant essentiellement un premier composé sélectionné dans le groupe se composant de glycoprotéine VIH Env gp 120, de glycoprotéine gp 160, et d'épitopes spécifiques de ces derniers composés, et un deuxième composé choisi dans le groupe se composant d'une chaîne lourde HLA de classe I (HC) associée ou non à de la microglobuline .beta.2 ou des fragments de cette dernière.

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