Use of antioxidants to mitigate radioimmunotherapy-induced...

Details Use of antioxidants to mitigate radioimmunotherapy-induced... Use of antioxidants to mitigate radioimmunotherapy-induced...

A - Human Necessities

61

K

A61K 31/375 (2006.01) A61K 31/07 (2006.01) A61K 31/355 (2006.01) A61K 41/00 (2006.01) A61K 51/10 (2006.01) A61P 39/06 (2006.01)

Patent

CA 2370600

The instant invention provides a method of using antioxidant, e.g., vitamins, as radioprotective agents to mitigate gastrointestinal and hemopoietic toxicity of the radioimmunotherapy. The instant invention further provides a method of combining the administration of antioxidant with BMT to produce an additive radioprotective effect against radiation damage to healthy tissues during the radioimmunotherapy.

L'invention concerne un procédé d'utilisation d'antioxydants, par exemple, des vitamines, en tant qu'agents radioprotecteurs afin d'alléger la toxicité gastro-intestinale et hématopoïétique de la radioimmunothérapie. Elle concerne, de plus, un procédé consistant à combiner l'administration d'un antioxydant avec BMT afin de produire un effet radioprotecteur supplémentaire contre les dommages provoqués par les rayons sur des tissus sains pendant la radioimmunothérapie.

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