Use of antisecretory factors for treating intraocular...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2650344

The present invention relates to the use of antisecretory factors, such as antisecretory proteins, homologues, derivatives and/or fragments thereof having antisecretory activity, for the manufacture of a pharmaceutical composition for use in the treatment and/or prevention of intraocular hypertension. The invention thus relates to the use of pharmaceutical compositions comprising antisecretory factors in the treatment and/or prevention of intraocular hypertension, which is preferably characterized by hampered outflow of body fluid resulting in elevated pressure in the eye. The invention provides for a novel approach for treating and/or preventing such a condition turning the intraocular pressure to an acceptable level, optionally 21 mm Hg, or less.

La présente invention concerne l'utilisation de facteurs antisécrétoires tels que des protéines antisécrétoires, des homologues, des dérivés et/ou des fragments de ceux-ci ayant une activité antisécrétoire, pour fabriquer une composition pharmaceutique destinée à être utilisée dans le traitement et/ou la prévention de l'hypertension intraoculaire. L'invention concerne donc l'utilisation de compositions pharmaceutiques comprenant des facteurs antisécrétoires dans le traitement et/ou la prévention de l'hypertension intraoculaire, qui se caractérise de préférence par une inhibition de l'écoulement d'un fluide biologique résultant d'une pression élevée dans l'oel. L'invention concerne une nouvelle approche du traitement et/ou de la prévention de ce trouble qui ramène la pression intraoculaire à un niveau acceptable, le cas échéant à 21 mmHg ou moins.

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