C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/24 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2223109
The present invention relates to oligonucleotides which are effective inhibitors of disease-associated cellular proliferation. The present invention relates to methods of treating disease-associated cellular proliferation using oligonucleotides. In particular, it relates to the use of oligonucleotides which are substantially complementary to interleukin-6 receptor mRNA sequences. In the form of pharmaceutical compositions, these oligonucleotides are suitable for administration to human subjects for the treatment of abnormal cellular proliferation due to such diseases as cancer, autoimmune disorders and viral infection.
L'invention porte sur des oligonucléotides s'avérant d'efficaces inhibiteurs de la prolifération cellulaire morbide. Elle porte également sur des procédés de traitement de ladite prolifération par les oligonucléotides et en particulier sur l'utilisation d'oligonucléotides sensiblement complémentaires des séquences de l'ARNm du récepteur de l'interleukine-6. Sous leur forme de préparations pharmaceutiques, ces oligonucléotides s'administrent à des patients pour traiter la prolifération cellulaire morbide liée à des maladies telles que le cancer, les troubles auto-immuns ou les infections virales.
Brown Steven Joel
Dattagupta Nanibhushan
Naidu Yathi M.
Gen-Probe Incorporated
Smart & Biggar
LandOfFree
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