Use of apo b secretion/mtp inhibitors

Details Use of apo b secretion/mtp inhibitors Use of apo b secretion/mtp inhibitors

A - Human Necessities

61

K

A61K 31/472 (2006.01) A61K 31/00 (2006.01) A61K 31/4468 (2006.01) A61K 31/454 (2006.01) A61K 45/06 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2324800

The invention provides methods useful in reducing intestinal fat absorption in an animal, preferably a mammal including a human subject or a companion animal, which methods comprise administering to an animal in need of such reduction, an amount of an apolipoprotein B (apo B) secretion/microsomal triglyceride transfer protein (MTP) inhibitor, preferably in combination with an anti-obesity agent. The invention further provides pharmaceutical compositions comprising amounts of an apo B secretion/MTP inhibitor and an anti-obesity agent, and to methods of using such compositions in reducing intestinal fat absorption in an animal, preferably a mammal including a human subject or a companion animal, in need of such reduction. The invention further provides a kit comprising an amount of an apolipoprotein B secretion/microsomal triglyceride transfer protein inhibitor and a pharmaceutically acceptable carrier, vehicle or diluent in a first unit dosage form; an amount of an anti-obesity agent and a pharmaceutically acceptable carrier, vehicle or diluent in a second unit dosage form; and a container.

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