A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/548 (2006.01) A61K 31/00 (2006.01) A61K 31/437 (2006.01) A61K 31/4402 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/4995 (2006.01) A61K 38/48 (2006.01) A61P 1/16 (2006.01)
Patent
CA 2496547
The present invention is based on the finding that the artificial induction of hepatic stellate cell (HSC) apoptosis in vivo can promote the resolution of liver fibrosis. Thus, the present invention provides methods for treating liver disease in a subject involving administration of an inducer of apoptosis which is capable of selectively inducing hepatic stellate cell apoptosis in the liver of the subject or of an agent which is capable of giving rise to such an inducer in the subject. In addition, the invention provides methods for treating liver fibrosis in a subject comprising the selective delivery of an inducer of apoptosis specifically to the hepatic stellate cells of the subject or of an agent which is capable of giving rise to an inducer of hepatic stellate cell apoptosis.
La présente invention concerne une découverte, à savoir l'induction artificielle de l'apoptose de cellules hépatiques stellaires (CHS) <i>in vivo</i> peut favoriser la résolution de la fibrose hépatique. Ainsi, on propose des méthodes de traitement de maladies hépatiques dont souffre un patient impliquant l'administration d'un inducteur de l'apoptose apte à induire sélectivement l'apoptose des cellules hépatiques stellaires dans le foie du patient ou d'un agent apte à donner lieu à un inducteur chez le patient. Par ailleurs, l'invention concerne des méthodes de traitement de la fibrose hépatique dont souffre un sujet consistant à administrer de manière sélective un inducteur de l'apoptose spécifiquement aux cellules hépatiques stellaires du patient ou un agent apte à donner lieu à un inducteur de l'apoptose de cellules hépatiques stellaires.
Arthur Michael James Paul
Benyon Christopher
Iredale John Peter
Mann Derek Austin
Murphy Frank
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
University Of Southampton
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