Use of apoptosis-specific eif-5a sirnas and antisense...

Details Use of apoptosis-specific eif-5a sirnas and antisense... Use of apoptosis-specific eif-5a sirnas and antisense...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01)

Patent

CA 2574190

The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.

La présente invention concerne le facteur d'initiation eucaryotique 5A (eIF-5A) spécifique de l'apoptose, désignés sous le nom de eIF-5A ou eIF5-A1 spécifiques de l'apoptose, des acides nucléiques et des procédés permettant l'inhibition ou la suppression de l'apoptose dans des cellules à l'aide de nucléotides antisens ou d'ARNsi pour inhiber l'expression de eIF-5A spécifique de l'apoptose. L'invention concerne également la suppression ou l'inhibition de cytokines pro-inflammatoires ou l'inhibition de l'activation de NFkB par l'inhibition de l'expression de eIF-5A spécifique de l'apoptose.

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