Use of aromatic hydrocarbons and silicone fluids for making...

Details Use of aromatic hydrocarbons and silicone fluids for making... Use of aromatic hydrocarbons and silicone fluids for making...

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) C07F 9/58 (2006.01) C07F 9/6506 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2657002

Provided is a novel method of making bisphosphonic acids, e.g. risedronic acid, including the step of combining a carboxylic acid, phosphorous acid, and a halophosphorous compound in the presence of a diluent that is an aromatic hydrocarbon or a silicone fluid. When the diluent is an aromatic hydrocarbon, an inert support or ortho- phosphoric acid codiluent is advantageously included.

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