C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/38 (2006.01) C07F 9/58 (2006.01) C07F 9/6506 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2485443
Provided is a novel method of making bisphosphonic acids, e.g. risedronic acid, including the step of combining a carboxylic acid, phoshorous acid, and a halophosphorous compound in the presence of a diluent that is an aromatic hydrocarbon or a silicone fluid. When the diluent is an aromatic hydrocarbon, a inert support or ortho-phosphoric acid codiluent is advantageously included.
L'invention concerne un procédé relatif à l'élaboration d'acides bisphosphoniques (par exemple, acide risedronique), qui consiste à combiner de l'acide carboxylique, de l'acide phosphoreux et un composé halophosphoreux en présence d'un diluant qui est un hydrocarbure aromatique ou un fluide siliconé. Lorsque le diluant est un hydrocarbure aromatique, il est préférable d'ajouter un support inerte ou un acide ortho-phosphorique co-diluant.
Har'el Zvi
Kovalevski-Ishai Eti
Lidor-Hadas Rami
Lifshitz-Liron Revital
Heenan Blaikie Llp
Teva Pharmaceutical Industries Ltd
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