Use of aryl n-substituted carboxamides to kill tumors

Details Use of aryl n-substituted carboxamides to kill tumors Use of aryl n-substituted carboxamides to kill tumors

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 31/167 (2006.01) A61K 31/44 (2006.01) A61K 31/455 (2006.01) A61K 33/24 (2006.01) C07C 237/30 (2006.01) C07C 237/34 (2006.01)

Patent

CA 2248109

Methods of killing tumor or cancer cells in human patients using an aryl N- substituted carboxamide having one or more aryl halo or one or more aromatic nitrogens, and/or acid addition salts thereof. The carboxamide may be an N- substituted nicotinamide or an N-substituted benzamide having such features, and may be used directly as a chemotherapeutic agent, or as a sensitizer for radiation or other chemotherapeutic agents. New compositions for such use include N-(2-diethylamino-ethyl)-4-amino-3-chlorobenzamide, N-(2-diethylamino- ethyl) nicotinamide, and their acid addition salts, e.g. hydrochlorides.

Cette invention se rapporte à des procédés permettant de tuer des cellules tumorales ou cancéreuses chez des patients humains grâce à l'utilisation d'un aryle carboxymide N-substitué ayant un ou plusieurs halo aryle ou un ou plusieurs azotes aromatiques, et/ou de sels d'addition d'acide de ces composés. Le carboxamide peut être un nicotinamide N-substitué ou un benzamide N-substitué présentant ces caractéristques, et il peut être utilisé directement en tant qu'agent chimiothérapeutique, ou en tant que sensibilisateur au rayonnement ou à d'autres agents chimiothérapeutiques. L'invention se rapporte à de nouvelles compositions destinées à une telle utilisation qui incluent le N-(2-diéthylamino-éthyl)-4-amino-3-chlorobenzamide, le N-(2-diéthylamino-éthyl) nicotinamide ainsi que leurs sels d'addition d'acide, par exemple des hydrochlorures.

Affiliated with

Also associated with

Rating

Use of aryl n-substituted carboxamides to kill tumors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of aryl n-substituted carboxamides to kill tumors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of aryl n-substituted carboxamides to kill tumors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1830054