A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/43 (2006.01) A61K 38/46 (2006.01) A61K 38/54 (2006.01) C12N 9/82 (2006.01)
Patent
CA 2368230
Described herein are methods for using asparaginases and/or glutaminases to treat patients with asparagine and/or glutamine-dependent diseases. Some diseases specifically envisioned to be treated by the methods of the invention include Graft versus Host disease and auto-immune diseases, including SLE, RA, diabetes, and AIDS. The glutaminases and asparaginases can be native or recombinant, and can be modified by acylation or pegylation, for example.
L'invention concerne des procédés consistant à utiliser des asparaginases et/ou des glutaminases afin de traiter des individus atteints de maladies dépendantes d'asparagine et/ou de glutamine. Ces maladies peuvent englober des maladies provoquées par le rejet du greffon ou des maladies auto-immunes, y compris le lupus érythémateux systémique, la polyarthrite rhumatoïde, le diabète ou le SIDA. Ces glutaminases et asparaginases peuvent être natives ou recombinantes et modifiées par acylation ou pegylation, par exemple.
Children's Hospital Los Angeles
Smart & Biggar
LandOfFree
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