Use of asymmetric membranes in delivery devices

A - Human Necessities – 61 – K

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167/153, 167/327

A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 9/28 (2006.01) A61K 9/36 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01)

Patent

CA 1338552

A device for controlled release of an active substance through one or more asymmetric membranes by diffusion and/or osmotic pumping. The active substance may typically be a pharmaceutically active substance such as antihypertensive and antianxiety agent to be released into the fluid of the gastro- intestinal tract of an animal over a prolonged period of time. The asymmetric membranes may be permeable and made of for example a cellulose ester or ethyl cellulose. The active substance may be released by osmotic pumping or by diffusion. Also disclosed is a process for producing the device by a phase inversion process. The asymmetric membrane is comprised of two membrane layers, one being a relatively thick and very porous substructure and the other being a very dense thin skin.

609559

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