Use of b7-h3 as an immunoregulatory agent

Details Use of b7-h3 as an immunoregulatory agent Use of b7-h3 as an immunoregulatory agent

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2521847

The present disclosure relates to the fields of immunology and clinical immunology, and more particularly to the use of B7-family ligands and agonists and antagonists thereof in modulation of immune response. The invention provides methods for modulation of lymphocyte activation involving the use of B7-H3, including B7-H3 VC and B7-H3 VCVC, and related molecules such as, for example, antibodies and nucleic acids.

La présente invention concerne les domaines de l'immunologie et de l'immunologie clinique et, notamment, l'utilisation de ligands de la famille B7 et d'agonistes et d'antagonistes associés dans la modulation de réponses immunitaires. Cette invention a aussi trait à des méthodes de modulation de l'activation de lymphocytes qui impliquent l'utilisation de B7-H3, y compris de B7-H3 VC et B7-H3 VCVC, et de molécules associées, telles que, par exemple, des anticorps et des acides nucléiques.

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