Use of benzimidazole quinolinones for treating cancer

Details Use of benzimidazole quinolinones for treating cancer Use of benzimidazole quinolinones for treating cancer

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61K 31/4375 (2006.01) A61K 31/4709 (2006.01) A61K 31/52 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 453/02 (2006.01) C07D 453/06 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2501932

Methods of treating cancer using 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1- yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one are provided. In particular, the methods are effective for the treatment of solid tumors or leukemias, including prostate, colorectal, breast, multiple myeloma, pancreatic, small cell carcinoma, acute myelogenous leukemia, chronic myelogenous leukemia, or myelo-proliferative disease. Further provided are methods of measuring the amount of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2- yl]quinolin-2(1H)-one and determining a metabolic profile therefore.

L'invention concerne des procédés de traitement du cancer par 4-amino-5-fluoro-3-[6-(4-méthylpipérazine-1-yle)-1H-benzimidazole-2-yle]quinoline-2(1H)-one, efficaces en particulier pour le traitement de tumeurs solides ou de la leucémie, y compris le cancer de la prostate, le cancer colorectal, le cancer du sein, le myélome multiple, le cancer du pancréas, le carcinome à cellules multiples, la LAM, la LMC, ou le syndrome myéloprolifératif. On décrit également des procédés visant à mesurer la quantité de 4-amino-5-fluoro-3-[6-(4-méthylpipérazine-1-yle)-1H-benzimidazole-2-yle]quinoline-2(1H)-one et à déterminer un profil métabolique correspondant.

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