Use of benzopyranols to treat neurological disorders

Details Use of benzopyranols to treat neurological disorders Use of benzopyranols to treat neurological disorders

A - Human Necessities

61

K

A61K 31/35 (2006.01) A61K 31/353 (2006.01)

Patent

CA 2266681

Benzopyran derivatives and analogs are disclosed as useful for the treatment and/or prophylaxis of degenerative diseases such as Huntingdon's chorea, schizophrenia, neurological deficits associated with AIDS, sleep disorders (including circadian rhythm disorders, insomnia and narcolepsy), tics (e.g. Gilles de la Tourette's syndrome), traumatic brain injury, tinnitus, neuralgia, especially trigeminal neuralgia, neuropathic pain, dental pain, cancer pain, inappropriate neuronal activity resulting in neurodysthesias in diseases such as diabetes, MS and motor neurone disease, ataxias, muscular rigidity (spasticity), temporomandibular joint dysfunction.

L'invention concerne des dérivés et analogues du benzopyrane utiles pour le traitement et/ou la prophylaxie de maladies dégénératives telles que: la chorée de Huntington, la schizophrénie, les déficits neurologiques associés au SIDA, les troubles du sommeil (y compris les dérèglements du rythme circadien, l'insomnie et la narcolepsie), les tics (maladie de Gilles de la Tourette, par exemple), les lésions traumatiques du cerveau, les acouphènes, les névralgies (en particulier la névralgie faciale), les douleurs neurogènes, dentaires, cancéreuses, l'activité neuronale inappropriée provoquant des neurodysthésies dans des maladies comme les diabètes, la sclérose en plaques et les maladies des motoneurones, les ataxies, la rigidité musculaire (hypertonie spastique), la dysfonction temporo-mandibulaire.

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