Use of .beta.galnac(1-4).beta.gal conjugates to treat...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) C07K 16/14 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2192827

A method of treating Candida albicans infection is disclosed. In one embodiment, for treatment of oral or vaginal infection, the treatment is by topical application of a composition of conjugates that are each composed of a carrier structure and multiple .beta.GalNac(1-4).beta.Gal moieties attached to the structure. In another embodiment, for treatment of systemic infection, the treatment is by parenteral administration of a humanized form of a mouse monoclonal antibody produced by mouse hybridoma cell line Fm16 or cell line PK99H.

Procédé de traitement d'une infection à Candida albicans. Selon un mode de réalisation se rapportant au traitement d'une infection buccale ou vaginale, le traitement s'effectue par application locale d'une composition de conjugués composés chacun d'une structure porteuse et de plusieurs fractions .beta.GalNac(1-4).beta.Gal fixées à cette structure. Selon un autre mode de réalisation se rapportant au traitement d'une infection générale, le traitement s'effectue par administration parentérale d'une forme humanisée d'un anticorps monoclonal murin produit par la lignée cellulaire Fm16 ou PK99H d'hybridome murin.

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