Use of beta-lapachone for protecting against radiation injury

Details Use of beta-lapachone for protecting against radiation injury Use of beta-lapachone for protecting against radiation injury

A - Human Necessities

61

K

A61K 31/352 (2006.01) A61K 41/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2546445

Administration of a modulator of cell cycle checkpoint activation, which is preferably .beta.-lapachone, or a pharmaceutically acceptable salt, prodrug, metabolite, analog or derivative thereof, protects normal cells against radiation injury. The invention includes methods of preventing radiation damage. The invention also provides methods for treating conditions such as cancer with radiotherapy, by administering a modulator of cell cycle checkpoint activation to a subject, prior to administration of radiotherapy.

L'administration d'un modulateur d'activation de points de contrôle de cycle cellulaire, de préférence, un .beta.-lapachone ou un sel pharmaceutiquement acceptable, un promédicament, un métabolite, un analogue ou un dérivé de celui-ci, protège les cellules normales contre les radiolésions. L'invention concerne des méthodes permettant de prévenir les radiolésions. L'invention concerne également des méthodes permettant de traiter des états tel que le cancer par radiothérapie, par administration d'un modulateur d'activation de points de contrôle de cycle cellulaire à un sujet avant d'administrer ladite radiothérapie.

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