Use of beta-sheet mimetics as protease and kinase inhibitors...

Details Use of beta-sheet mimetics as protease and kinase inhibitors... Use of beta-sheet mimetics as protease and kinase inhibitors...

C - Chemistry, Metallurgy

07

D

C07D 471/12 (2006.01) A61K 31/40 (2006.01) A61K 31/4035 (2006.01) A61K 31/407 (2006.01) A61K 31/415 (2006.01) A61K 31/4152 (2006.01) A61K 31/428 (2006.01) A61K 31/435 (2006.01) A61K 31/437 (2006.01) A61K 31/50 (2006.01) A61K 31/5025 (2006.01) A61K 38/00 (2006.01) A61K 38/04 (2006.01) A61K 38/55 (2006.01) C07C 49/527 (2006.01) C07D 209/04 (2006.01) C07D 471/04 (2006.01) C07K 1/04 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01) C07K 5/097 (2006.01) C07K 5/117 (2006.01) C07K 7/06 (2006.0

Patent

CA 2262900

.beta.-sheet mimetics and methods relating to the same are disclosed. The .beta.-sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors. Methods of the invention include administration of a .beta.-sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase and/or transcription factor.

L'invention concerne des mimétiques de feuillets bêta et des procédés les concernant. Les mimétiques de feuillets bêta sont utiles comme inhibiteurs de protéase et de kinase ainsi que comme inhibiteurs de facteurs de transcription. Des procédés de l'invention comprennent l'administration d'un mimétique de feuillets bêta ou l'utilisation dudit mimétique pour fabriquer un médicament destiné au traitement d'une variété d'états pathologiques associés à la protéase, à la kinase et/ou au facteur de transcription ciblés.

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