A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/19 (2006.01) A61K 31/045 (2006.01) A61K 31/047 (2006.01) A61K 31/075 (2006.01) A61K 31/122 (2006.01) A61K 31/133 (2006.01) A61K 31/15 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/196 (2006.01) A61K 31/215 (2006.01) A61K 31/216 (2006.01) A61K 31/235 (2006.01) A61K 31/56 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2215067
A composition and method of inhibiting tumor growth and treating malignant melanoma without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs of tumor. Betulinic acid is obtained by the steps of preparing an extract from the stem bark of Ziziphus mauritiana to mediate selective cytotoxic profile against human melanoma in the subject panel of human cancer cell lines, conducting a bioassay-directed fractionation based on the profile of biological activity using cultured human melanoma cells as the monitor, and obtaining betulinic acid.
Composition et procédé servant à inhiber la croissance de tumeurs et à traiter le mélanoblastome sans effets secondaires toxiques. L'acide bétulinique ou un dérivé d'acide bétulinique est le composé actif de la composition, qu'on applique localement à l'emplacement de la tumeur. L'acide bétulinique s'obtient par préparation d'un extrait de l'écorce de la tige de Ziziphus mauritania afin de produire un profil cytotoxique sélectif contre le mélanome de l'homme dans le groupe concerné de lignées de cellules du cancer de l'homme, par réalisation d'un fractionnement effectué dans un dosage biologique se basant sur le profil d'activité biologique au moyen de cellules cultivées du mélanome de l'homme en tant qu'élément de contrôle, ce qui permet d'obtenir l'acide bétulinique.
Dasgupta Tapas K.
Pezzuto John M.
Ridout & Maybee Llp
The Board Of Trustees Of The University Of Illinois
LandOfFree
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