Use of biarylcarboxamides in the treatment of hedgehog...

Details Use of biarylcarboxamides in the treatment of hedgehog... Use of biarylcarboxamides in the treatment of hedgehog...

A - Human Necessities

61

K

A61K 31/24 (2006.01) A61K 31/17 (2006.01) A61K 31/341 (2006.01) A61K 31/343 (2006.01) A61K 31/4164 (2006.01) A61K 31/4409 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2648196

The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway. In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of the invention (e.g., a compound of Formula I).

Cette invention concerne des méthodes permettant de moduler, par exemple d'antagoniser, l'activité de la voie de signalisation Hedgehog. Cette invention concerne en particulier des méthodes permettant d'inhiber des états de croissance aberrante résultant de phénotypes tels que la perte de fonction du gène Ptc, le gain de fonction du gène Hedgehog, le gain de fonction du gène Smoothened ou le gain de fonction du gène Gli, lesquels méthodes consistent à mettre une cellule en contact avec une quantité suffisante d'un composé de cette invention (tel qu'un composé représenté par la formule (I)).

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