Use of biguanide derivatives for making a medicine having a...

A - Human Necessities – 61 – K

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A61K 31/155 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2410025

The invention concerns the use of biguanide derivatives of general formula (I) wherein: groups R1 and R2 represent, independently of each other, a hydrogen atom, a C¿1?-C¿7? alkyl group, a cycloalkyl group, a heterocycle, a C¿2?-C¿7? alkenyl group, an aryl group, an aralkyl group, an aryloxyalkyl group or a heteroaryl group or R1 and R2 together represent a C¿2?-C¿7? alkylene group capable of containing one or several heteroatoms and group R3 represent a primary, secondary or tertiary amine and their pharmaceutically acceptable salts for making a medicine having a wound healing effect, said medicine being in a pharmaceutical form for topical use.

La présente invention concerne l'utilisation de dérivés de biguanide de formule générale (I) dans laquelle: les groupes R1 et R2 représentent, indépendamment l'un de l'autre, un atome d'hydrogène, un groupe alkyle en C1- C7, un groupe cycloalkyle, un hétérocycle, un groupe alcényle en C2-C7, un groupe aryle, un groupe aralkyle, un groupe aryloxylalkyle ou un groupe hétéroaryle ou R1 et R2 pris ensemble représentent un alkylène en C2-C7 pouvant contenir un ou plusieurs hétéroatomes et le groupe R3 représente une amine primaire, secondaire ou tertiaire ou de leurs sels pharmaceutiquement acceptables pour fabriquer un médicament ayant un effet cicatrisant, ledit médicament étant sous une forme pharmaceutique à usage topique.

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