Use of bioactive glass compositions to stimulate osteoblast...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/00 (2006.01) C12N 5/077 (2010.01) A61K 33/00 (2006.01) A61L 27/10 (2006.01)

Patent

CA 2414510

Compositions comprising bioactive glass compositions or extracts thereof which include ions in an appropriate concentration and ratio that they enhance osteoblast production, and methods of preparation and use thereof, are disclosed. The compositions can be included in implantable devices that are capable of inducing tissue formation in autogeneic, allogeneic and xenogeneic implants, for example as coatings and/or matrix materials. Examples of such devices include prosthetic implants, sutures, stents, screws, plates, tubes, and the like. Aqueous extracts of the bioactive glass compositions, which extracts are capable of stimulating osteoblast production, are also disclosed. The compositions can be used, for example, to induce local tissue formation from a progenitor cell in a mammal, for accelerating allograft repair in a mammal, for promoting in vivo integration of an implantable prosthetic device to enhance the bond strength between the prosthesis and the existing target tissue at the joining site, and for treating tissue degenerative conditions.

L'invention concerne des compositions renfermant des compositions de verre bioactif ou des extraits correspondants qui contiennent des ions dans une concentration et un taux adéquats leur permettant d'améliorer la production d'ostéoblaste, ainsi que des méthodes de préparation et d'utilisation correspondantes. On peut incorporer lesdites compositions dans des dispositifs implantables qui peuvent induire la formation tissulaire dans des autogreffes, allogreffes et xénogreffes, par exemple des revêtements et/ou des matières à matrice. Des exemples de tels dispositifs englobent des prothèses, des sutures, des stents, des vis, des plaques, des tubes et similaire. Cette invention concerne également des extraits aqueux de compositions de verre bioactif qui peuvent stimuler la production d'ostéoblaste. On peut utiliser ces compositions, par exemple, pour induire la formation tissulaire locale à partir d'une cellule souche chez un mammifère, afin d'accélérer la réparation de l'allogreffe chez ledit mammifère, de promouvoir l'intégration in vivo d'un appareil prothétique implantable de manière à améliorer la force d'adhésion entre la prothèse et les tissus cibles existants au niveau du site d'accolement, et de traiter des conditions tissulaires dégénératives.

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