Use of biomolecular targets in the treatment and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 49/00 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2469480

The present invention relates to the use of a protein that is differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as a biomolecular target for tumor treatment therapies. The protein is also expressed in tissues from adenocarcinoma, non-melanoma, and renal carcinoma cells. Immunotherapeutic and immunoimaging agents that specifically bind to an identified brain tumor target protein are provided. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.

La présente invention porte sur l'utilisation d'une protéine comme cible biomoléculaire dans les traitements des tumeurs, cette protéine étant exprimée de manière différentielle dans les tissus primaires d'une tumeur au cerveau, par rapport aux tissus normaux du cerveau. La protéine est également exprimée dans les tissus d'un adénocarcinome, d'un cancer non mélanique et d'un hypernéphrome. L'invention porte également sur des agents immunothérapeutiques et d'immuno-imagerie qui se lient spécifiquement à une protéine cible identifiée d'une tumeur au cerveau. La présente invention porte encore sur des composés et des compositions acceptables d'un point de vue pharmaceutique et destinés à être administrés dans les procédés précités.

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