A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/66 (2006.01) A61K 31/59 (2006.01) A61K 31/663 (2006.01) A61P 19/00 (2006.01)
Patent
CA 2308532
The present invention relates to a procedure applicable to medical preparations of bisphosphonates and their formulations for the treatment of Osteogenesis Imperfecta. This procedure consists of the administration of bisphophonate preparation to a patient requiring treatment in a first stage to obtain a defined bone mineral density. Then the administration of the bisphosphonate preparation is interrupted in a second stage to allow for architectonic expression of bone. The length of the second stage can be determined by means of a tomography. In other words, the periods of administration or non-administration of the mineralizing agent are defined or controlled by precise osteologic variables and therefore are not fixed. If during the second stage the cortical mineral density drops by 6-10% of the maximum value previously obtained, administration of bisphosphonate preparation should be resumed until the corresponding maximum adjusted value is reached again. The proposed procedure of a period comprising bisphosphonate administration followed by a period of non-administration of the bisphosphonate agent improves fracture resistance, provided that the length of both periods is controlled by defined osteologic variables.
Lloret Anibal Perez
Roldan Emilio J.a.
G. Ronald Bell & Associates
Gador S.a.
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